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Single-Dose Zilebesiran Cuts BP Out to 6 Months: KARDIA-2: This phase 2 study supports the potential for combining biannual dosing of zilebesiran with ...
medscape.com/viewarticle/single-dose-zilebesiran-cuts-bp-out-6-months-kardia-2-2024a100073r
Single-Dose Zilebesiran Cuts BP Out to 6 Months: KARDIA-2
Quick Glance: Zilebesiran: Long-Term Blood Pressure Reduction in KARDIA-2
  • Administering a single subcutaneous dose of the RNA interference agent zilebesiran resulted in significant decreases in systolic blood pressure compared to placebo at 3 months when incorporated into a standard antihypertensive therapy in the KARDIA-2 study.

  • These effects persisted for up to 6 months in the majority of patients, despite the addition of supplementary antihypertensive treatment.

  • Regarding side effects, treatment with zilebesiran was linked to higher rates of mild hyperkalemia, hypotension, and a decrease in estimated glomerular filtration rate, with most cases being non-severe, temporary, and resolving without intervention.

  • The detailed outcomes of the KARDIA-2 study were unveiled by Akshay Desai, MD, a cardiologist at Brigham and Women's Hospital in Boston, Massachusetts, during the recent American College of Cardiology Annual Scientific Session held in Atlanta, Georgia.
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A woman with failing kidneys receives genetically modified pig organs : Surgeons transplanted a kidney and thymus gland from a gene-edited pig into a 54-year-old ...
npr.org/sections/health-shots/2024/04/24/1246577224/gene-edited-pig-kidney-transplant-nyu
A woman with failing kidneys receives genetically modified pig organs
Quick Glance: Revolutionary Transplant: Heart Pump and Pig Kidney
  • The first transplant surgery combining a mechanical heart pump and a gene-edited pig kidney was successfully performed at NYU Langone Health.

  • The patient, 54-year-old Lisa Pisano from New Jersey, received the heart pump and pig kidney due to heart failure and end-stage kidney disease.

  • Experts view xenotransplants as crucial to addressing organ shortages by transplanting animal organs into humans.

  • Gene editing aims to prevent the human immune system from rejecting the animal organs, facilitating successful transplantations.
Profile picture of Healthline
Treating High Blood Pressure May Help Reduce The Risk of Developing Fibroids: Hypertension medications are associated with a lower risk of uterine fibroids in ...
healthline.com/health-news/treating-high-blood-pressure-may-help-reduce-the-risk-of-developing-fibroids
Treating High Blood Pressure May Help Reduce The Risk of Developing ...
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Plant-Based Diet for Treating and Reversing Stage 3 Kidney Disease | NutritionFacts.org
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Plant-Based Diet for Treating and Reversing Stage 3 Kidney Disease | ...
Profile picture of Healthline
Swapping Salt with Substitutes May Lower Your Risk of Death from Heart Disease: Replacing regular salt with healthier substitutions may help lower your risk of ...
healthline.com/health-news/salt-substitutes-heart-disease-risk
Swapping Salt with Substitutes May Lower Your Risk of Death from Heart ...
Profile picture of The New York Times
Grandmother Becomes Second Patient to Receive Kidney From Gene-Edited Pig: NYU Langone Health surgeons performed the transplant after implanting a mechanical ...
nyti.ms/3xZ8GQK
Grandmother Becomes Second Patient to Receive Kidney From Gene-Edited Pig
Profile picture of Richmond Times-Dispatch
Altria's Tina Turner show shut down for false fire alarm incident: A Friday evening showing at the Altria Theater in downtown Richmond came to a halt at 9:45 p.m ...
richmond.com/news/local/altrias-tina-turner-show-shut-down-for-false-fire-alarm-incident/article_f6530ed2-f3ff-11ee-94fe-f389fa037368.html
Altria's Tina Turner show shut down for false fire alarm incident
Profile picture of Focus (Polish magazine)
89 percent of all heart patients make a serious mistake: Too much salt is bad for your health - especially when it comes to cardiovascular diseases ...
focus.de/gesundheit/ratgeber/herz/risiko/bluthochdruck/neue-studienergebnisse-sie-essen-zu-viel-salz-das-kann-der-grund-fuer-herz-kreislauf-erkrankung-sein_id_259833277.html
89 percent of all heart patients make a serious mistake
Profile picture of Richmond Times-Dispatch
Shooting on North 23rd Street in Richmond kills man: Richmond police are investigating a fatal shooting that occurred Saturday morning in the 2200 block of North ...
richmond.com/news/local/crime/shooting-on-north-23rd-street-in-richmond-kills-man/article_433e0ec8-f46d-11ee-a6f4-4f015267c7f6.html
Shooting on North 23rd Street in Richmond kills man
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Hearing canal: An app just for the kidneys: Kidneys suffer silently and secretly, symptoms usually appear very late. A new app may be able to prevent early ...
spektrum.de/podcast/eine-app-nur-fuer-die-niere/2214099
Hearing canal: An app just for the kidneys
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Houston hospital halts liver and kidney transplants as it investigates ‘inappropriate changes’ to patient records
cnn.com/2024/04/12/health/houston-hospital-halts-liver-and-kidney-transplants-as-it-investigates-inappropriate-changes-to-patient-records/
Houston hospital halts liver and kidney transplants as it investigates ...
Profile picture of Healthline
Your Guide to Blurry or Hazy Vision: Blurry vision is a disturbance in your eyesight that makes it difficult to see. Learn more about the causes, symptoms ...
healthline.com/health/hazy-vision
Your Guide to Blurry or Hazy Vision
Profile picture of Daily Record (Scotland)
Jack Butland on why Rangers anthem resonates with family: Simply the Best was a staple in the Butland household long before the goalkeeper was walking out to it ...
dailyrecord.co.uk/sport/football/football-news/jack-butland-reveals-rangers-anthem-32525524
Jack Butland on why Rangers anthem resonates with family
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Consequences of aging, why we die explained by Nobel biologist: Ramakrishnan explains why we may not want to lengthen our lives much longer.
abcnews.go.com/US/consequences-aging-die-explained-nobel-biologist/story
Consequences of aging, why we die explained by Nobel biologist
Profile picture of USA Today
What causes nosebleeds? And why some people get them more than others.: Nosebleeds can be the result of someone blowing their nose too hard or because an ...
usatoday.com/story/life/health-wellness/2024/04/09/what-causes-nosebleeds/73053814007/
What causes nosebleeds? And why some people get them more than others.
Profile picture of The Indian Express
All the ways a hotter planet makes us sicker: A study of 266 studies worldwide, published in 2022, revealed that heat waves were associated with a 11 ...
indianexpress.com/article/opinion/columns/all-the-ways-a-hotter-planet-makes-us-sicker-9291068/
All the ways a hotter planet makes us sicker
Profile picture of Electrek
BMW unveils 2025 i4 with a reimagined gloss black front end and sportier digitized interior
electrek.co/2024/04/24/bmw-unveils-2025-i4-reimagined-gloss-black-front-end-sportier-digitized-interior/
BMW unveils 2025 i4 with a reimagined gloss black front end and sportier ...
Profile picture of The Washington Post
They were bitter rivals. Then one of them needed a kidney.: It was a long journey for James Harris and Russ Redhead to become close enough that they now wear ...
washingtonpost.com/lifestyle/2024/04/09/pool-player-rival-kidney-donation/
They were bitter rivals. Then one of them needed a kidney.
Profile picture of AsiaOne
'Allow people to have better control of their life': NKF expands overnight dialysis with over 200 new slots
asiaone.com/singapore/allow-people-have-better-control-their-life-nkf-expands-overnight-dialysis-over-200-new
'Allow people to have better control of their life': NKF expands ...
Profile picture of Daily Breeze
Dietary choices are linked to higher rates of preeclampsia among Latinas: For pregnant Latinas, food choices could reduce the risk of preeclampsia ...
bostonherald.com/2024/04/23/dietary-choices-are-linked-to-higher-rates-of-preeclampsia-among-latinas/
Dietary choices are linked to higher rates of preeclampsia among Latinas
Profile picture of Car and Driver
2025 BMW i4 EV and 4-Series Gran Coupe Get Revised Kidney Grilles: Along with both Bimmers getting restyled faces and interior tweaks, the gas-fed Gran Coupe ...
caranddriver.com/news/a60583892/2025-bmw-i4-ev-4-series-gran-coupe-updated-details/
2025 BMW i4 EV and 4-Series Gran Coupe Get Revised Kidney Grilles
Profile picture of Nottinghamshire Live
Dr Michael Mosley says one food in diet can reduce blood pressure: Dr Michael Mosley has shared a simple way to reduce your risk of heart disease and high blood ...
nottinghampost.com/news/health/dr-michael-mosley-says-adding-9244785
Dr Michael Mosley says one food in diet can reduce blood pressure
Profile picture of Daily Sabah
Türkiye’s sole kidney transplant hospital performed 75 transplants: The Gaziantep University Kahraman Eruslu Kidney Transplant Hospital, Türkiye's first and ...
dailysabah.com/turkiye/turkiyes-sole-kidney-transplant-hospital-performed-75-transplants/news
Türkiye’s sole kidney transplant hospital performed 75 transplants
Profile picture of Medical Tribune
Gastrointestinal tract and renal replacement procedures: Like Dr. Nicola Wilck, Charité - Universitätsmedizin Berlin, the accumulation of uremic toxins from a ...
medical-tribune.de/medizin-und-forschung/artikel/zahlreiche-interaktionen-zwischen-magen-darm-und-niere
Gastrointestinal tract and renal replacement procedures
Profile picture of The Punch
Neurologists warn long-term stress may cause memory loss  - Healthwise: Prolonged exposure to stress can heighten the chances of experiencing anxiety and ...
healthwise.punchng.com/neurologists-warn-long-term-stress-may-cause-memory-loss/
Neurologists warn long-term stress may cause memory loss  - Healthwise
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Counties with the highest rates of high blood pressure in Kentucky: Stacker compiled a list of counties with the highest rates of high blood pressure in Kentucky ...
kentucky.com/news/local/article288010130.html
Counties with the highest rates of high blood pressure in Kentucky
Profile picture of thedailystar.net
Heatwave putting strain on kidney, heart hospitals: Amid the blistering heatwave across the country, specialized hospitals in the capital are grappling with an ...
thedailystar.net/news/bangladesh/news/heatwave-putting-strain-kidney-heart-hospitals-3595486
Heatwave putting strain on kidney, heart hospitals
Profile picture of Deutsches Ärzteblatt
Atrial fibrillation in younger people more dangerous than expected: Pittsburgh - The increasing number of younger people with high blood pressure, diabetes ...
aerzteblatt.de/nachrichten/150916/Vorhofflimmern-bei-juengeren-Menschen-gefaehrlicher-als-angenommen
Atrial fibrillation in younger people more dangerous than expected
Profile picture of Runner's World
This is how running improves your blood pressure: Here you can find out how you can improve your blood pressure by jogging. » For an overview of current research ...
runnersworld.de/verletzungen-vorbeugung/wie-laufen-den-blutdruck-beeinflusst/
This is how running improves your blood pressure
Profile picture of MIT Technology Review
The Download: hyperrealistic deepfakes, and clean energy’s implications for mining
technologyreview.com/2024/04/25/1091830/the-download-hyperrealistic-deepfakes-and-clean-energys-implications-for-mining/
The Download: hyperrealistic deepfakes, and clean energy’s implications ...
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Lauterbach wants new regulations on organ donation, but “ethical questions must not be underestimated”
berliner-zeitung.de/gesundheit-oekologie/lauterbach-will-neuregelung-der-organspende-aber-ethische-fragen-duerfen-nicht-unterschaetzt-werden-li.2209136
Lauterbach wants new regulations on organ donation, but “ethical questions ...
Profile picture of Lancs Live
Doting dad died in 'extremely rare' Sharm-el-Sheikh holiday tragedy: "He died doing something that he loved and it's a comfort to know he wouldn't ...
lancs.live/news/lancashire-news/holiday-tragedy-doting-dad-granddad-29052027
Doting dad died in 'extremely rare' Sharm-el-Sheikh holiday tragedy
Profile picture of Miami Herald
Impatient drivers turn traffic lights into aggression. I call it the Miami Millisecond | Opinion
miamiherald.com/opinion/article287939655.html
Impatient drivers turn traffic lights into aggression. I call it the Miami ...
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Boxing coach Mayowa seeks support for kidney treatment: Coach Lasisi Mayowa, affectionately known as Coach Mayor within the boxing community ...
punchng.com/boxing-coach-mayowa-seeks-support-for-kidney-treatment/
Boxing coach Mayowa seeks support for kidney treatment
Profile picture of Health
Signs and Symptoms of Glaucoma: Glaucoma is a group of eye diseases that can damage the optic nerve and cause blindness. Symptoms may include partial vision loss ...
health.com/glaucoma-symptoms-8548474
Signs and Symptoms of Glaucoma
Profile picture of The Plain Dealer
Playhouse Square announces 2024-2025 Broadway in Akron show lineup: Playhouse Square has announced the show lineup for its 2024-2025 Broadway in Akron Series ...
cleveland.com/entertainment/2024/04/playhouse-square-announces-2024-2025-broadway-in-akron-show-lineup.html
Playhouse Square announces 2024-2025 Broadway in Akron show lineup
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Blood pressure therapy could prevent uterine fibroids: Oakland - In a US cohort study, women with untreated hypertension had an increased risk of uterine ...
dlvr.it/T5vTHm
Blood pressure therapy could prevent uterine fibroids
Profile picture of The Indian Express
Army tribunal restores Honorary Lieutenant rank to subedar after post was withdrawn over hypertension condition
indianexpress.com/article/cities/chandigarh/army-tribunal-honorary-lieutenant-rank-subedar-hypertension-9286163/
Army tribunal restores Honorary Lieutenant rank to subedar after post was ...
Profile picture of Runner's World
Doctors Removed a Cancerous Tumor From His Kidney. Eight Months Later, He Ran the Boston Marathon.
runnersworld.com/runners-stories/a60571659/boston-marathon-runner-cancer-recovery/
Doctors Removed a Cancerous Tumor From His Kidney. Eight Months Later ...
Profile picture of nw.de
New rules should enable more kidney donations: In Germany, thousands of patients have to wait a long time for urgently needed donor organs - including kidneys ...
nw.de/nachrichten/nachrichten/23837086_Neue-Regeln-sollen-mehr-Nierenspenden-ermoeglichen.html
New rules should enable more kidney donations
Profile picture of Taipei Times
Many over-40s have one of ‘three highs’: Bringing Taiwan to the World and the World to Taiwan
taipeitimes.com/News/taiwan/archives/2024/04/23/2003816831
Many over-40s have one of ‘three highs’
Profile picture of The Local
Today in Germany: A roundup of the latest news on Tuesday: Germany moves in on suspected spies for China, including reportedly an AfD employee ...
thelocal.de/20240423/today-in-germany-a-roundup-of-the-latest-news-on-tuesday-21
Today in Germany: A roundup of the latest news on Tuesday
Profile picture of The Punch
Physicians concerned as half of Nigerians with hypertension not on treatment: As hypertension prevalence rises in Nigeria amid skyrocketing drug prices ...
punchng.com/physicians-concerned-as-half-of-nigerians-with-hypertension-not-on-treatment/
Physicians concerned as half of Nigerians with hypertension not on ...
Profile picture of Health
Health Benefits of Sesame Seeds: Sesame seeds offer many nutrients, including fiber and B vitamins. Benefits may include lowering cholesterol and blood pressure.
health.com/sesame-seeds-benefits-8627888
Health Benefits of Sesame Seeds
Profile picture of The Kansas City Star
My Uncle Ed gave the gift of life after his death. He inspired me to become a living donor | Opinion
kansascity.com/opinion/article287716885.html
My Uncle Ed gave the gift of life after his death. He inspired me to ...
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'Why drinking cold water despite hot weather is dangerous' - Healthwise
healthwise.punchng.com/why-drinking-cold-water-despite-hot-weather-is-dangerous/
'Why drinking cold water despite hot weather is dangerous' - ...
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Mediterranean Diet Tied to Lower Blood Pressure, Greek Study Shows - GreekReporter.com
greekreporter.com/2024/04/19/mediterranean-diet-lower-blood-pressure/
Mediterranean Diet Tied to Lower Blood Pressure, Greek Study Shows - ...
Profile picture of The Times
Inside the lab planning to transplant pigs’ hearts into babies: Perceptions of animal organs change when lives depend on them, say scientists who are optimistic ...
thetimes.co.uk/article/pig-heart-transplant-human-first-8x9k7pppt
Inside the lab planning to transplant pigs’ hearts into babies
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Cardiologist busts notions of ‘good’ and ‘bad’ habits: A cardiologist explains the perception of bad habits, and their impact on human health ...
thehindu.com/sci-tech/health/cardiologist-busts-notions-of-good-and-bad-habits/article68075586.ece
Cardiologist busts notions of ‘good’ and ‘bad’ habits
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Medical emergencies in dentistry - Guyana Chronicle: FROM the time I became a practicing dentist more than three decades ago, the thing I fear most in this ...
guyanachronicle.com/2024/04/21/medical-emergencies-in-dentistry/
Medical emergencies in dentistry - Guyana Chronicle
Profile picture of Daily Record (Scotland)
Scots lad spends more than 100 days in hospital after transplant health battle: George Leishman, has survived serious complications from a major operation which ...
dailyrecord.co.uk/news/scottish-news/scots-lad-spends-more-100-32615003
Scots lad spends more than 100 days in hospital after transplant health ...
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It’s plain as porridge! Oats are full of health benefits, despite what the haters on social media say
dailymaverick.co.za/article/2024-04-20-its-plain-as-porridge-oats-are-full-of-health-benefits/
It’s plain as porridge! Oats are full of health benefits, despite what the ...
Profile picture of Houston Chronicle
Houston TX high school student suffers aneurysm, makes it to prom: Cypress Woods, Texas high school student Michael Ozurumba recovers from brain aneurysm in time ...
houstonchronicle.com/health/article/houston-high-school-student-recovers-from-aneurysm-19405844.php
Houston TX high school student suffers aneurysm, makes it to prom
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Drug shortages: supply problems with generics for patients with high blood pressure
echo-online.de/ratgeber/gesundheit/medikamentenmangel-wie-die-versorgung-bei-bluthochdruck-ist-3484605
Drug shortages: supply problems with generics for patients with high blood ...
Profile picture of Vox
How much does a kidney cost, and why aren’t donors paid for giving one?: Giving a kidney saves a life. Paying donors could fix the shortage.
vox.com/future-perfect/24131207/kidney-donation-compensation-tax-credit-end-kidney-deaths-act
How much does a kidney cost, and why aren’t donors paid for giving one?
Profile picture of allgemeine-zeitung.de
Kidney disease: Mainzer has been a dialysis patient for 50 years: Willi Koller never got a new kidney. That's why the 70-year-old has had to go to "blood wash" ...
allgemeine-zeitung.de/lokales/mainz/stadt-mainz/mainzer-willi-koller-ist-seit-50-jahren-dialysepatient-3498723
Kidney disease: Mainzer has been a dialysis patient for 50 years
Profile picture of The Columbian
Vancouver man killed in crash on Highway 14 in Skamania County: A Vancouver man died in a crash on Highway 14 in Skamania County late Thursday evening.
columbian.com/news/2024/apr/19/vancouver-man-killed-in-crash-on-highway-14-in-skamania-county/
Vancouver man killed in crash on Highway 14 in Skamania County
Profile picture of Metro (British newspaper)
James Whale worries he 'might not make the end of year' amid terminal cancer: Veteran broadcaster and TalkTV star James Whale has said he is uncertain about how ...
metro.co.uk/2024/04/17/james-whale-worries-might-not-make-end-year-amid-terminal-cancer-20669039/
James Whale worries he 'might not make the end of year' amid terminal ...